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In a very research in breast most cancers cells, the combination of lapatinib, a dual HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented each HER2 and HER3 phosphorylation induced by INK128 and developed synergistic induction of mobile death in several HER2-optimistic mobile strains resistant to trastuzumab and lapatinib. In vivoBe